Early Detection Research Network

8 Gene Panel for Barretts Esophagus

This biomarker is also known as:
  • 8-gene Panel for Barrett's Esophagus,
  • 8 Gene Panel for Barretts Esophagus,
  • Meltzer 8-marker panel for Esophageal Adenocarcinoma,


Eight methylation biomarkers - p16, RUNX3, HPP1 (HGNC name TMEFF2), NELL1, TAC1, SST, AKAP12 and CDH13 - were tested in a restrospective multicenter double-blinded validation study for their accuracy in predicting neoplastic progression in Barretts Esophagus. Hypermethylation of p16, RUNX3 and HPP1 has been show to occur in early Barretts Esophagus-related neoplastic progression and predicts progression risk. Several of the panel (NELL1, TAC1, SST, AKAP12 and CDH13) were also shown to be methylated early and often in Barretts Esophagus-related neoplastic progression.

QA State: Accepted
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

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