Early Detection Research Network

http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/53/74/sensitivity-data-20

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Risk stratification of BE patients by predictiveness curves of 8-marker panel, age alone, and 8-marker-plus-age panel in combined, 2-year and 4-year prediction models. A, Predictiveness curve of 8-marker panel in combined model. After rigorous overfitting correction, at risk = 0.1 and = 0.5, 45% and 4% of subjects had estimated risks below 0.1 (LR group) and above 0.5 (HR group), respectively; while remaining 51% had estimated risks between 0.1 and 0.5 (IR group). B, Predictiveness curves of age alone and of 8-marker-plus-age panel in combined model. After rigorous overfitting correction, BE patients were stratified into LR (15%) and IR (85%) groups by age alone. BE patients were stratified into LR (51%), IR (44%) and HR (5%) groups by 8-marker-plus-age panel. C, Predictiveness curve of 8-marker panel in 2-year model. After rigorous overfitting correction, BE patients were stratified into LR (45%), IR (51%) and HR (4%) groups. D, Predictiveness curves of age alone and of 8-marker-plus-age panel in 2-year model. After rigorous overfitting correction, BE patients were stratified into LR (11%) and IR (89%) groups by age alone. BE patients were stratified into LR (52%), IR (44%) and HR (4%) groups by the 8-marker-plus-age panel. E, Predictiveness curve of the 8-marker panel alone in the 4-year model. After rigorous overfitting correction, BE patients were stratified into LR (44%), IR (51%) and HR (5%) groups. F, Predictiveness curves of age alone and of the 8-marker-plus-age panel in the 4-year model. After rigorous overfitting correction, BE patients were stratified into LR (15%) and IR (85%) groups by age alone. BE patients were stratified into LR (51%), IR (44%) and HR (5%) groups by 8-marker-plus-age panel. LR: low-risk; IR, intermediate-risk; HR: high-risk; OC: overfitting correction. Graphs in Related Resources section, file "NP-P Supplementary fig 2.ppt". [8]