Early Detection Research Network

ACKR3

Aliases:
This biomarker is also known as:
  • Chemokine orphan receptor 1,
  • G-protein coupled receptor RDC1 homolog,
  • G-protein coupled receptor 159,
  • RDC-1,
  • CXCR7,
  • CXC-R7,
  • P25106,
  • ACKR3,
  • GPR159,
  • CMKOR1,
  • chemokine orphan receptor 1,
  • CXCR-7,
  • G protein-coupled receptor,
  • C-X-C chemokine receptor type 7,
  • RDC1,
  • chemokine (C-X-C motif) receptor 7,

Description…

ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. ACKR3 is also a coreceptor for human immunodeficiency viruses (HIV).

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: ACKR3

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.