Early Detection Research Network

ACKR3

Aliases:
This biomarker is also known as:
  • chemokine (C-X-C motif) receptor 7,
  • CXCR7,
  • C-X-C chemokine receptor type 7,
  • RDC1,
  • Chemokine orphan receptor 1,
  • P25106,
  • RDC-1,
  • CMKOR1,
  • ACKR3,
  • chemokine orphan receptor 1,
  • G-protein coupled receptor 159,
  • G protein-coupled receptor,
  • CXCR-7,
  • GPR159,
  • CXC-R7,
  • G-protein coupled receptor RDC1 homolog,

Description…

ACKR3 (CXCR7, CMKOR1) is a member of the G-protein coupled receptor family. It is a receptor for chemokines CXCL12/SDF1 and CXCL11. ACKR3 does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. ACKR3 is also a coreceptor for human immunodeficiency viruses (HIV).

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: ACKR3

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

No additional ovarian data available.

Performance Comment

ACKR3 (CXCR7, CMKOR1) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. ACKR3 (CXCR7, CMKOR1) was not in the group of 13 selected for further validation.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.