Early Detection Research Network


This biomarker is also known as:
  • ferritin repressor protein,
  • citrate hydro-lyase,
  • Citrate hydro-lyase,
  • iron-responsive element binding protein 1,
  • IRE-BP 1,
  • aconitate hydratase,
  • Ferritin repressor protein,
  • Iron-responsive element-binding protein 1,
  • ACO1,
  • Iron regulatory protein 1,
  • IREBP,
  • cytoplasmic aconitate hydratase,
  • iron regulatory protein 1,
  • aconitase 1, soluble,
  • iron-responsive element-binding protein 1,
  • IREB1,
  • EC,
  • ACONS,
  • IRP1,
  • Aconitase,
  • IREBP1,


aconitase 1, soluble


There are no datasets associated with this biomarker.

QA State: Curated
Type: Gene

The following organs have data associated with this biomarker…


Phase: One
QA State: Under Review


No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.

No other associated resources found.