Early Detection Research Network

Esophagus

Esophageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/52/73
Accepted
Two
Promoter hypermethylation of AKAP12 occurs early during Barrett's-associated esophageal neoplastic progression. Studies investigating potential use of this protein as a biomarker are ongoing.
075ce52b1cf34fe2879d50ab75fb70d1
no
no
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