Early Detection Research Network

Prostate

AMACR is overexpressed in prostate cancer and may be useful in the interpretation of prostate needle biopsy specimens that are diagnostically challenging.
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/119/143
Curated
Three
Increased AMACR transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.
8591e8b29d1543d691241e7a3f33de65
no
no
Contents
Canary TMA

Primary Objective •   To validate established tissue biomarkers that predict recurrent disease as defined by serum PSA level and therapy following radical prostatectomy. Secondary Objectives •   To identify candidate biomarkers that predict non-recurrent disease. •   To identify candidate tissue biomarkers that predict recurrent disease as defined by serum PSA level and therapy following radical prostatectomy