Early Detection Research Network

ANGPTL3

Aliases:
This biomarker is also known as:
  • Angiopoietin-5,
  • Angiopoietin-like protein 3,
  • angiopoietin-like 3,
  • FHBL2,
  • ANGPT5,
  • angiopoietin-related protein 3,
  • ANGPTL3,
  • angiopoietin 5,
  • ANG-5,

Description…

ANGPTL3, or angiopoietin-like 3, is a member of the angiopoietin-like family of secreted factors. It is a secreted protein expressed primarily in the liver, and also weakly expressed in the kidney. ANGPTL3 has the characteristic angiopoietin structure, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. ANGPTL3 is also thought to be involved in the regulation of angiogenesis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: ANGPTL3

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.