Early Detection Research Network

ANXA1

Aliases:
This biomarker is also known as:
  • LPC1,
  • Annexin-1,
  • Annexin I,
  • ANX1,
  • Annexin A1,
  • Calpactin II,
  • Annexin 1,
  • ANXA1,
  • Chromobindin-9,
  • Lipocortin I,
  • Phospholipase A2 inhibitory protein,
  • p35,

Description…

Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. Annexin 1 also promotes membrane fusion and is involved in exocytosis. It seems to bind from two to four calcium ions with high affinity.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: ANXA1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.