Early Detection Research Network


This biomarker is also known as:
  • apoptotic peptidase activating factor 1,
  • apoptotic protease activating factor,
  • KIAA0413,
  • apoptotic protease-activating factor 1,
  • APAF-1,
  • apoptotic peptidase activating factor,
  • CED4,


APAF1 is a cytoplasmic protein that initiates apoptosis. APAF1 binds cytochrome c and dATP, forming an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.


There are no datasets associated with this biomarker.

QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: APAF1

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

APAF1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.