Early Detection Research Network

APEX1

Aliases:
This biomarker is also known as:
  • APEX,
  • APEX Nuclease,
  • Deoxyribonuclease (Apurinic Or Apyrimidinic),
  • REF1,
  • AP Endonuclease 1,
  • APE1,
  • Apurinic-Apyrimidinic Endonuclease 1,
  • Redox Factor-1,
  • APEX Nuclease (Multifunctional DNA Repair Enzyme),
  • APX,
  • APEX1,
  • APEX Nuclease (Multifunctional DNA Repair Enzyme) 1,
  • Protein REF-1,
  • HAP1,
  • AP Endonuclease Class I,
  • APEN,
  • AP Lyase,
  • APE,
  • EC 4.2.99.18,
  • APE-1,
  • Apurinic/Apyrimidinic (Abasic) Endonuclease,
  • REF-1,
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase,

Description…

APEX1 is the major endonuclease in human cells, playing a role in DNA repair and the celluar response to oxidative stress. APEX1 is an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Several splice variants have been identified for this gene, all encoding the same protein.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: APEX1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.