Early Detection Research Network

ARHGEF16

Aliases:
This biomarker is also known as:
  • Rho guanine nucleotide exchange factor (GEF) 16,
  • ephexin-4,
  • Ephexin-4,
  • EPHEXIN4,
  • rho guanine nucleotide exchange factor 16,
  • Rho guanine exchange factor (GEF) 16,
  • GEF16,
  • NBR,
  • ARHGEF16,

Description…

ARHGEF16 is a guanine nucleotide exchange factor. Guanine nucleotide exchange factors regulate the activation of Rho-like GTPases. Guanidine exchange factors promote the GTP activation of Rho GTPase's by catalyzing the exchange of GDP for GTP.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: ARHGEF16

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

ARHGEF16 is a nucleotide exchange factor involved in regulating the activation of Rho-like GTPases. When the regulation occurs incorrectly, ARHGEF16 and other nucleotide exchange factors can aid malignant transformation.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.