Early Detection Research Network

ATP6V1G1

Aliases:
This biomarker is also known as:
  • V-ATPase subunit G 1,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J,
  • ATP6GL,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1,
  • V-ATPase 13 kDa subunit 1,
  • V-type proton ATPase subunit G 1,
  • vacuolar H(+)-ATPase subunit G 1,
  • ATP6G1,
  • ATP6J,
  • vacuolar proton pump subunit G 1,
  • Vacuolar proton pump subunit G 1,
  • vacuolar proton pump subunit M16,
  • vacuolar ATP synthase subunit M16,
  • Vacuolar proton pump subunit M16,
  • DKFZp547P234,
  • ATP6G,
  • Vma10,
  • ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1,

Description…

ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: ATP6V1G1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

ATP6V1G1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.