Early Detection Research Network

BCAM

Aliases:
This biomarker is also known as:
  • CD239,
  • Lutheran antigen,
  • basal cell adhesion molecule (Lu and Au blood groups),
  • MSK19,
  • basal cell adhesion molecule (Lutheran blood group),
  • F8/G253 antigen,
  • Basal cell adhesion molecule,
  • B-CAM cell surface glycoprotein,
  • Lutheran blood group (Auberger b antigen included),
  • Lutheran blood group glycoprotein,
  • LU,
  • CD_antigen=CD239,
  • AU,
  • Auberger B antigen,

Description…

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin alpha-5. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. It may also play a role in intracellular signalling. BCAM has wide tissue distribution (highest in the pancreas and very low in brain) and is closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Two transcript variants encoding different isoforms have been found for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: BCAM

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated

Overview

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.

No other associated resources found.