Early Detection Research Network

CCL5

Aliases:
This biomarker is also known as:
  • eoCP,
  • D17S136E,
  • beta-chemokine RANTES,
  • RANTES,
  • SIS-delta,
  • Small-inducible cytokine A5,
  • C-C motif chemokine 5,
  • Eosinophil chemotactic cytokine,
  • T-cell specific protein p288,
  • EoCP,
  • eosinophil chemotactic cytokine,
  • small inducible cytokine subfamily A (Cys-Cys), member 5,
  • SCYA5,
  • small inducible cytokine A5 (RANTES),
  • chemokine (C-C motif) ligand 5,
  • T cell-specific protein P228,
  • T-cell-specific protein RANTES,
  • CCL5,
  • SISd,
  • t cell-specific protein P228,
  • regulated upon activation, normally T-expressed, and presumably secreted,
  • TCP228,
  • small-inducible cytokine A5,
  • MGC17164,

Description…

From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: CCL5

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

The chemokine CCL5 (RANTES), a major monocyte chemoattractant expressed by breast tumor cells, has been implicated in the progression of breast cancer.

Performance Comment

CCL5 (RANTES) was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.