Early Detection Research Network

CD59

Aliases:
This biomarker is also known as:
  • MIN3,
  • MSK21,
  • CD59,
  • Protectin,
  • 16.3A5,
  • CD59 antigen, complement regulatory protein,
  • G344,
  • HRF-20,
  • 20 kDa homologous restriction factor,
  • 1F5 antigen,
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344),
  • Membrane inhibitor of reactive lysis,
  • MIRL,
  • CD59 glycoprotein,
  • MIN2,
  • EL32,
  • MACIF,
  • MAC-inhibitory protein,
  • EJ30,
  • EJ16,
  • MEM43 antigen,
  • MIN1,
  • p18-20,
  • MAC-IP,
  • Membrane attack complex inhibition factor,
  • MIC11,

Description…

CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific and is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: CD59

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.