Early Detection Research Network

p16

Aliases:
This biomarker is also known as:
  • CDK4I,
  • Multiple tumor suppressor 1,
  • p19,
  • CDKN2A,
  • p16-INK4a,
  • INK4,
  • p16,
  • Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3,
  • CMM2,
  • MTS1,
  • p16INK4a,
  • CDKN2,
  • INK4a,
  • Cyclin-dependent kinase 4 inhibitor A,

Description…

The CDKN2A locus generates several transcript variants which differ in their first exons. Two distinct transcripts are produced from different promoters: p16 (INK4A) and p14 (ARF). At least three alternatively spliced variants encoding distinct proteins have been reported, two of which (p16 and p14) encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Attributes
QA State: Curated
Type: Genomic
HGNC Name: CDKN2A

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.