Early Detection Research Network

Chen 10-marker miRNA signature for non-small cell lung cancer

Aliases:
This biomarker is also known as:
  • Chen 10-marker miRNA signature for non-small cell lung cancer,

Description…

A panel of 10 serum miRNAs has been identified that were found to have significantly different expression levels in non-small cell lung cancer (NSCLC) serum samples compared with the control serum samples. This panel of miRNAs was able to distinguish NSCLC cases from controls with high sensitivity and specificity. The ten miRNAs are: miR-20a, miR-24, miR-25, miR-145, miR-152, miR-199a-5p, miR-221, miR-222, miR-223, miR-320.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

No member markers defined for this panel.

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

This panel of miRNAs was able to distinguish NSCLC cases from controls with high sensitivity and specificity.

Performance Comment

Under ROC curves, the AUC for tumor identification in training set and validation set were 0.966 and 0.972, respectively. Furthermore, the expression profile of the 10-serum miRNAs was correlated with the stage of NSCLC patients, especially in younger patients and patients with current smoking habits. (from PMID:21557218)

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.

No other associated resources found.