Early Detection Research Network


This biomarker is also known as:
  • HC-gp39,
  • YYL-40,
  • chitinase 3-like 1 (cartilage glycoprotein-39),
  • 39 kDa synovial protein,
  • CHI3L1,
  • CGP-39,
  • Cartilage glycoprotein 39,
  • Chitinase-3-like protein 1,
  • hCGP-39,
  • YKL40,
  • ASRT7,
  • GP-39,
  • GP39,
  • YKL-40,
  • FLJ38139,
  • DKFZp686N19119,
  • HCGP-3P,
  • Chitinase,


CHI3L1, also known as chitinase, a secreted protein, is a carbohydrate-binding lectin with a preference for chitin. It may play a role in defense against pathogens, or in tissue remodeling. It may also play an important role in the capacity of cells to respond to and cope with changes in their environment. CHI3L1 is present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It is undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Curated


CHI3L1, also commonly known as chitinase or YKL-40, has been studied as a biomarker for disease onset and progression for a variety of cancers.

Performance Comment

Of the ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. CHI3L1 (chitinase) alone was not a strong predictor.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.