Early Detection Research Network

CTNNB1

Aliases:
This biomarker is also known as:
  • Catenin (Cadherin-Associated Protein), Beta 1 (88kD),
  • Catenin Beta-1,
  • NEDSDV,
  • Armadillo,
  • CTNNB,
  • CTNNB1,
  • Beta-Catenin,
  • Catenin (Cadherin-Associated Protein), Beta 1, 88kDa,
  • Catenin Beta 1,
  • EVR7,
  • Catenin (Cadherin-Associated Protein), Beta 1,
  • MRD19,

Description…

From NCBI Gene: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Proteomic
HGNC Name: CTNNB1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.