Early Detection Research Network

DCC

Aliases:
This biomarker is also known as:
  • DCC,
  • deleted in colorectal carcinoma,
  • Tumor suppressor protein DCC,
  • CRCR1,
  • CRC18,
  • colorectal cancer suppressor,
  • Immunoglobulin superfamily DCC subclass member 1,
  • deleted in colorectal cancer protein,
  • Colorectal cancer suppressor,
  • IGDCC1,
  • colorectal tumor suppressor,
  • tumor suppressor protein DCC,
  • immunoglobulin superfamily DCC subclass member 1,
  • netrin receptor DCC,
  • immunoglobulin superfamily, DCC subclass, member 1,

Description…

DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: DCC

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.

Attributes

Phase: Two
QA State: Under Review

Overview

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.