Early Detection Research Network


This biomarker is also known as:
  • deleted in colorectal carcinoma,
  • Colorectal cancer suppressor,
  • CRCR1,
  • Immunoglobulin superfamily DCC subclass member 1,
  • colorectal tumor suppressor,
  • tumor suppressor protein DCC,
  • colorectal cancer suppressor,
  • CRC18,
  • Tumor suppressor protein DCC,
  • DCC,
  • IGDCC1,
  • deleted in colorectal cancer protein,
  • netrin receptor DCC,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • immunoglobulin superfamily DCC subclass member 1,


DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: One
QA State: Curated


No additional data available.

Performance Comment

DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.


Phase: Two
QA State: Under Review


Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.