Early Detection Research Network

DCP

Aliases:
This biomarker is also known as:
  • Prothrombin Induced by Vitamin K Absence II,
  • DCP,
  • Des-gamma carboxyprothrombin,
  • PIVKA II,

Description…

Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal hemostasis. Functional prothrombin contains several gamma-carboxy-glutamic acid (Gla) residues that are produced as the result of post-translational modification of glutamic acid residues mediated by vitamin K dependent gamma-glutamyl carboxylase. The formation of Gla residues can be impaired in patients with vitamin K deficiency or in patients receiving oral anticoagulant therapy. DCP lacks thrombotic activity and has been shown in multiple studies to be present in the serum of patients with HCC. DCP arises from an acquired defect in the post-translational carboxylation of the pro-thrombin precursor in malignant hepatocytes.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name:

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.