Early Detection Research Network


This biomarker is also known as:
  • beta-defensin 1,
  • HBD-1,
  • DEFB-1,
  • beta-defensin-1,
  • defensin, beta 1,
  • DEFB1,
  • Defensin, beta 1,
  • hBD-1,
  • BD1,
  • BD-1,
  • P60022,
  • HBD1,
  • DEFB101,


DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. DEFB1 is thought to be involved in the pathogenesis of cystic fibrosis.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


No additional ovarian data available.

Performance Comment

DEFB1 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. DEFB1 was not in the group of 13 selected for further validation.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.