Early Detection Research Network


This biomarker is also known as:
  • Des-ubiquitin,
  • des-Gly-Gly-ubiquitin,


Des-ubiquitin is formed when a cysteine protease cleaves two carboxy-terminal glycine residues from ubiquitin.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Proteomic
HGNC Name:

The following organs have data associated with this biomarker…


Phase: One
QA State: Under Review


Cathepsin B, which is a cysteine protease, cleaves 2 terminal glycine residues of ubiquitin generating des-ubiquitin. Both monomeric ubiquitin and des-ubiquitin corresponding to m/z values 8,565 and 8,451 are among the 9 candidates of the signature described in the Rahman 9-marker MALDI MS panel for Lung Cancer study.

Performance Comment

Des-ubiquitin belongs to a 9-member panel that provides a quantitative measure of the probability of having lung cancer that goes beyond the histological evaluation of preinvasive lesions. The identified members of the panel are TMSB4X (Thymosin beta-4), Ubiquitin, des-ubiquitin, ACBP, CSTA, Cytochrome C, and MIF.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.

No other associated resources found.