Early Detection Research Network

DPP4

Aliases:
This biomarker is also known as:
  • adenosine deaminase complexing protein 2,
  • dipeptidylpeptidase 4,
  • T-cell activation antigen CD26,
  • dipeptidyl peptidase 4,
  • dipeptidyl peptidase IV,
  • Adenosine deaminase complexing protein 2,
  • DPP IV,
  • DPPIV,
  • Dipeptidyl peptidase IV,
  • CD26 antigen,
  • ADABP,
  • CD26,
  • dipeptidyl-peptidase 4,
  • TP103,
  • EC 3.4.14.5,
  • DPP4,
  • dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2),
  • ADCP2,
  • ADCP-2,

Description…

From NCBI Gene: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: DPP4

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

19 common probe sets (15 unique genes) were used to develop a PAM-based classifier, which had an average accuracy of 87% when it was tested on 47 independent tumor-adjacent stroma samples. The 15 genes represented in the classifier are: GADD45B, CDKN1A, NLRP1, ERBB3, FMO5, KIAA0746///SERINC2, AMFR, DPP4, PGC, YWHAE, EHF, TF, TNFSF10, EIF5A, TGM4. This is the first general tumor microenvironment-based prognostic classifier. Tumor-adjacent prostate cancer stroma contains numerous changes in gene expression at the time of diagnosis that correlate with the chance of relapse following prostatectomy. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.