Early Detection Research Network

E2F1

Aliases:
This biomarker is also known as:
  • RBBP-3,
  • Retinoblastoma-binding protein 3,
  • retinoblastoma-associated protein 1,
  • E2F-1,
  • RBP3,
  • RBBP3,
  • PBR3,
  • PRB-binding protein E2F-1,
  • RBAP1,
  • E2F1,
  • transcription factor E2F1,
  • retinoblastoma-binding protein 3,
  • Retinoblastoma-associated protein 1,
  • E2F transcription factor 1,
  • RBAP-1,

Description…

The E2F1 protein belongs to the E2F/DP family of transcription factors. E2F1 binds DNA cooperatively with dp (differentiation regulated transcription factor proteins)proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. E2F1 can mediate both cell proliferation and p53-dependent/independent apoptosis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: E2F1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.