Early Detection Research Network

EEF1A1

Aliases:
This biomarker is also known as:
  • Prostate Tumor-Inducing Protein 1,
  • Leukocyte Receptor Cluster (LRC) Member 7,
  • CCS-3,
  • CCS3,
  • GRAF-1EF,
  • Eukaryotic Elongation Factor 1 A-1,
  • EE1A1,
  • Elongation Factor 1-Alpha 1,
  • EF1A,
  • Elongation Factor Tu,
  • Leukocyte Receptor Cluster Member 7,
  • EF-Tu,
  • Cervical Cancer Suppressor 3,
  • EF-1-alpha-1,
  • Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14,
  • Elongation Factor 1 Alpha Subunit,
  • Translation Elongation Factor 1 Alpha 1-Like 14,
  • CTCL Tumor Antigen,
  • LENG7,
  • EF1a-Like Protein,
  • EEF1A1,
  • eEF1A-1,
  • Glucocorticoid Receptor AF-1 Specific Elongation Factor,
  • PTI1,
  • EEF1A,
  • HNGC:16303,
  • Eukaryotic Translation Elongation Factor 1 Alpha 1,
  • EEF-1,

Description…

From NCBI Entrez Gene: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: EEF1A1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

EEF1A is overexpressed in some lung cancers.

Performance Comment

Measurements of the 5 most predictive phage proteins were combined in a logistic regression model that achieved 90% sensitivity and 95% specificity in prediction of patient samples, whereas leave-one-out statistical analysis achieved 88.9% diagnostic accuracy among all 81 samples. (Zhong et. al. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1308-14. Epub 2005 Aug 18) The five proteins are GAGE7, BAC clone RP11-499F19, SEC15L2, PMS2P7 (PMS2L15), and EEF1A1.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.