Early Detection Research Network

EGFL6

Aliases:
This biomarker is also known as:
  • MAM and EGF domains-containing gene protein,
  • epidermal growth factor-like protein 6,
  • EGF repeat-containing protein 6,
  • EGF-like protein 6,
  • EGF-like-domain, multiple 6,
  • W80,
  • Q8IUX8,
  • EGFL6,
  • MAM and EGF domain containing,
  • MAEG,

Description…

EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the regulation of cell cycle, proliferation, and developmental processes. The presence of a signal peptide indicates it is a secreted protein. The EGFL6 gene is expressed during early development.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: EGFL6

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

EGFL6 is a secreted tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.

Performance Comment

EGFL6 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of EGFL6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.