Early Detection Research Network


This biomarker is also known as:
  • epidermal growth factor-like protein 6,
  • EGFL6,
  • EGF repeat-containing protein 6,
  • Q8IUX8,
  • MAEG,
  • EGF-like-domain, multiple 6,
  • W80,
  • EGF-like protein 6,
  • MAM and EGF domains-containing gene protein,
  • MAM and EGF domain containing,


EGFL6 is a member of the epidermal growth factor (EGF) repeat superfamily. This family is characterized by EGF-like repeats. Members are involved in the regulation of cell cycle, proliferation, and developmental processes. The presence of a signal peptide indicates it is a secreted protein. The EGFL6 gene is expressed during early development.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


EGFL6 is a secreted tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.

Performance Comment

EGFL6 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of EGFL6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.