Early Detection Research Network

EHF

Aliases:
This biomarker is also known as:
  • ETS domain-containing transcription factor,
  • ETS homologous factor,
  • Epithelium-specific Ets transcription factor 3,
  • ESEJ,
  • ESE3B,
  • EHF,
  • ets homologous factor,
  • epithelium-specific Ets transcription factor 3,
  • ESE3,
  • ESE-3,
  • hEHF,
  • ESE3 transcription factor,

Description…

From NCBI Gene: This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: EHF

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

19 common probe sets (15 unique genes) were used to develop a PAM-based classifier, which had an average accuracy of 87% when it was tested on 47 independent tumor-adjacent stroma samples. The 15 genes represented in the classifier are: GADD45B, CDKN1A, NLRP1, ERBB3, FMO5, KIAA0746///SERINC2, AMFR, DPP4, PGC, YWHAE, EHF, TF, TNFSF10, EIF5A, TGM4. This is the first general tumor microenvironment-based prognostic classifier. Tumor-adjacent prostate cancer stroma contains numerous changes in gene expression at the time of diagnosis that correlate with the chance of relapse following prostatectomy. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.