Early Detection Research Network

EIF3E

Aliases:
This biomarker is also known as:
  • Eukaryotic Translation Initiation Factor 3 Subunit 6,
  • Viral Integration Site Protein INT-6 Homolog,
  • Mammary Tumor-Associated Protein INT6,
  • EIF-3 P48,
  • eIF3e,
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD),
  • EIF3S6,
  • EIF3E,
  • INT6,
  • Murine Mammary Tumor Integration Site 6 (Oncogene Homolog),
  • Eukaryotic Translation Initiation Factor 3, Subunit E,
  • EIF3-P48,
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa,
  • eIF3-p46,
  • Eukaryotic Translation Initiation Factor 3 Subunit E,

Description…

From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: EIF3E

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.