Early Detection Research Network

Breast

EIF3E is one of the most statistically significant antigens in terms of its contribution to classification performance, along with SF3A1, and MYOZ2. (PMID:20977275) Additionally, data from another study suggests that eIF3e has a positive role in breast cancer progression. It regulates the translation, and in some cases abundance, of mRNAs involved in key aspects of cancer cell biology. (PMID:20453879)
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/522/436
Under Review
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EIF3E is a member of a 28 autoantibody (AAb) classifier that was developed with a sensitivity of 80.8% and a specificity of 61.6% (AUC=0.756). The 28 autoantibodies are potential biomarkers for breast cancer both individually and as members of the classifier.
2839dbb194a34f52ad2984f6be51c0c3
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