Early Detection Research Network

EIF5A

Aliases:
This biomarker is also known as:
  • EIF-5A,
  • eIF-5A,
  • Eukaryotic initiation factor 5A isoform 1,
  • eukaryotic translation initiation factor 5A,
  • eIF5AI,
  • rev-binding factor,
  • MGC99547,
  • MGC104255,
  • EIF5A,
  • eIF-5A1,
  • eukaryotic translation initiation factor 5A-1,
  • eIF-4D,
  • EIF5A1,
  • eIF-5A-1,
  • Rev-binding factor,
  • eukaryotic initiation factor 5A,

Description…

From UniProtKB/Swiss-Prot: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: EIF5A

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.