Early Detection Research Network

EPCAM

Aliases:
This biomarker is also known as:
  • TACSTD1,
  • MOC31,
  • MK-1,
  • DIAR5,
  • Ep-CAM,
  • GA733-2,
  • ESA,
  • 17-1A,
  • antigen identified by monoclonal antibody AUA1,
  • KSA,
  • KS1/4,
  • EGP314,
  • TACST-1,
  • Ly74,
  • MH99,
  • EGP40,
  • M4S1,
  • HEA125,
  • CD326,
  • tumor-associated calcium signal transducer 1,
  • HNPCC8,
  • EGP-2,
  • epithelial cell adhesion molecule,
  • MIC18,
  • EGP34,
  • 323/A3,
  • EPCAM,
  • TROP1,
  • CO-17A,

Description…

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. The EPCAM antigen, a single-pass type 1 membrane protein, is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. EPCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. EPCAM p-regulates the expression of FABP5, MYC and cyclins A and E. EPCAM is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: EPCAM

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.