Early Detection Research Network

ERBB3

Aliases:
This biomarker is also known as:
  • p45-sErbB3,
  • Proto-oncogene-like protein c-ErbB-3,
  • c-erbB3,
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian),
  • c-erbB-3,
  • MDA-BF-1,
  • p180-ErbB3,
  • ERBB3,
  • erbB3-S,
  • receptor tyrosine-protein kinase erbB-3,
  • lethal congenital contracture syndrome 2,
  • p85-sErbB3,
  • HER3,
  • LCCS2,
  • Tyrosine kinase-type cell surface receptor HER3,
  • proto-oncogene-like protein c-ErbB-3,
  • ErbB-3,
  • EC 2.7.10.1,
  • tyrosine kinase-type cell surface receptor HER3,

Description…

From NCBI Gene: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: ERBB3

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.