Early Detection Research Network

ESM1

Aliases:
This biomarker is also known as:
  • ESM1,
  • endothelial cell-specific molecule 1,
  • ESM-1,
  • endocan,

Description…

ESM1, a secreted protein containing multiple polyadenylation and mRNA instability signals, may have potent implications in lung endothelial cell-leukocyte interactions. It is expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. The expression of the ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Two transcript variants encoding different isoforms have been found for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: ESM1

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Under Review

Overview

ESM1 is a secreted tumor vascular marker (TVM) that is selectively expressed in tumor vasculature and represents a promising target for vascular imaging or anti-vascular therapy of epithelial ovarian cancer.

Performance Comment

ESM1 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ESM1 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.