Early Detection Research Network


This biomarker is also known as:
  • SEC15B,
  • SEC15L2,
  • Exocyst Complex Component 6B,
  • SEC15 Homolog B (S. Cerevisiae),
  • WUGSC:H_NH0343N14.1,
  • SEC15 Homolog B,
  • SEC15-Like 2,
  • SEC15-Like 2 (S. Cerevisiae),
  • SEC15-Like Protein 2,
  • EXOC6B,
  • KIAA0919,
  • Exocyst Complex Component Sec15B,


From NCBI Entrez Gene: In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.[supplied by OMIM, Apr 2004]


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: One
QA State: Curated


EXOC6B, or SEC15L2, has been found to be immunoreactive with plasma from patients with advanced-stage lung cancers. EXOC6B has no other known malignant association. (Zhong et. al. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1308-14. Epub 2005 Aug 18.)

Performance Comment

Measurements of the five most predictive antibody markers in 46 cases and controls were combined in a logistic regression model that yielded area under the receiver operating characteristics curve of 0.99; leave-one-out validation achieved 91.3% sensitivity and 91.3% specificity. (Zhong et al., J Thorac Oncol. 2006 Jul;1(6):513-9) The five antibody markers are PXN, EXOC6B (known as SEC15L2 in the publication), BAC clone RP11-499F19, XRCC5, and MALAT1.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.