Early Detection Research Network


This biomarker is also known as:
  • Apo-1 antigen,
  • Fas AMA,
  • apoptosis antigen 1,
  • CD95,
  • FAS,
  • TNFRSF6,
  • Fas (TNF receptor superfamily, member 6),
  • FASTM,
  • apoptosis-mediating surface antigen FAS,
  • CD95 antigen,
  • APT1,
  • tumor necrosis factor receptor superfamily, member 6,
  • tumor necrosis factor receptor superfamily member 6,
  • APO-1 cell surface antigen,
  • APO-1,
  • FASLG receptor,
  • FAS (Ab2),
  • Apoptosis-mediating surface antigen FAS,
  • FAS (Ab1),
  • FAS 827dupA,
  • ALPS1A,
  • Delta Fas/APO-1/CD95,
  • FAS1,


FAS is a member of the TNF-receptor superfamily. The FAS protein is a receptor for TNFSF6/FASLG and has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

FAS was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


Phase: Three
QA State: Under Review


APO-1/Fas receptor (FasR) is a cell surface receptor that, when activated, triggers apoptosis. It has been postulated that this receptor may be involved in the clearance of benign ovarian epithelial inclusion cysts (IC). An observed decreased expression of FasR in malignant ovarian epithelial neoplasms as compared with benign ovarian epithelial lesions suggests that a decreased sensitivity to Fas-mediated apoptosis may be involved in ovarian epithelial carcinogenesis.

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.