Early Detection Research Network

FHIT

Aliases:
This biomarker is also known as:
  • dinucleosidetriphosphatase,
  • Fragile histidine triad protein,
  • EC 3.6.1.29,
  • AP3A hydrolase,
  • diadenosine 5',5'''-P1,P3-triphosphate hydrolase,
  • FHIT,
  • fragile histidine triad gene,
  • tumor suppressor protein,
  • bis(5'-adenosyl)-triphosphatase,
  • FRA3B,
  • Diadenosine 5',5'''-P1,P3-triphosphate hydrolase,
  • AP3Aase,
  • Dinucleosidetriphosphatase,

Description…

FHIT, or fragile histidine triad, is a member of the histidine triad gene family. The FHIT protein is a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Included in the FHIT gene is the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. Mutated transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. There are several alternatively spliced transcript variants for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: FHIT

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.