Early Detection Research Network

FSH

Aliases:
This biomarker is also known as:
  • follicle stimulating hormone, beta polypeptide,
  • follicle-stimulating hormone beta subunit,
  • FSH-B,
  • follitropin, beta chain,
  • Follitropin beta chain,
  • FSH-beta,
  • Follitropin subunit beta,
  • FSHB,
  • FSH,

Description…

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. FSHB belongs to the glycoprotein hormones subunit beta family. There are two transcript variants from alternative splicing that each encode the same protein.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: FSHB

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated

Overview

It is uncertain if FSH levels are related to ovarian cancer risk. Conclusions from different studies show conflicting results.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.