Early Detection Research Network

FZD10

Aliases:
This biomarker is also known as:
  • Fz10,
  • Q9ULW2,
  • CD350 antigen,
  • FZ-10,
  • frizzled homolog 10,
  • frizzled homolog 10 (Drosophila),
  • FZD10,
  • Fz-10,
  • hFz10,
  • frizzled (Drosophila) homolog 10,
  • CD350,
  • frizzled-10,
  • FzE7,
  • frizzled family receptor 10,
  • frizzled 10, seven transmembrane spanning receptor,

Description…

FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins (WNT signaling proteins). The highest levels of expression for FZD10 are seen in the placenta and fetal kidney, followed by fetal lung and brain. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: FZD10

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

FZD10 may be considered for further preclinical testing as a tumor biomarker.

Performance Comment

FZD10 was overexpressed in ovarian cancer relative to normal ovary and relative to a panel of normal organs. FZD10 was detected in vascular structures by in situ hybridization in five independent ovarian cancer samples. FZD10 was found in small and larger blood vessels. FZD10 showed limited or no expression by qRT-PCR in normal tissues.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.