Early Detection Research Network

GAGE7

Aliases:
This biomarker is also known as:
  • GAGE-7B,
  • GAGE-8,
  • G Antigen 12G,
  • Cancer/Testis Antigen Family 4,
  • GAGE-7,
  • GAGE7,
  • AL4,
  • Member 7,
  • Cancer/Testis Antigen 4.7,
  • CT4.7,
  • GAGE12I,
  • GAGE7B,
  • GAGE-12I,
  • Cancer/Testis Antigen Family 4, Member 7,
  • G Antigen 7,

Description…

GAGE7 is a member of a family of genes that code for an antigenic peptide, YRPRPRRY. These genes are thought to be expressed in a variety of tumors but not in normal tissues, except for the testis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: GAGE7

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

GAGE7, a cancer testis antigen, is overexpressed in some lung cancers.

Performance Comment

Measurements of the 5 most predictive phage proteins were combined in a logistic regression model that achieved 90% sensitivity and 95% specificity in prediction of patient samples, whereas leave-one-out statistical analysis achieved 88.9% diagnostic accuracy among all 81 samples. (Zhong et. al. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1308-14. Epub 2005 Aug 18) The five proteins are GAGE7, BAC clone RP11-499F19, SEC15L2, PMS2P7 (PMS2L15), and EEF1A1.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.