Early Detection Research Network

Ovary

GDF15 is a member of the transforming growth factor-beta (TGF-beta) superfamily. It has been studied as a prognostic biomarker for a variety of cancers, including pancreatic, ovarian, and colorectal.
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/235/270
Under Review
Three
Of the ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. GDF15, also known as MIC1, alone was not a strong predictor.
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Contents
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study

Create a new set of phase II specimens (160 cases with pre-operative bloods representing major histologic types and including 80 early-staged and 80 late-staged cases, 160 controls with benign disease, 480 general population controls, and a small set of serial Samples collected either at least 3 months apart, but not more than 6 months apart OR between 10 months apart and no more than 14 months apart in 40 healthy controls) will be used to evaluate markers identified in preliminary work. The top 5-10 markers, plus an expanded panel of Luminex markers, will comprise a “working consensus panel” for subsequent analysis in PLCO specimens.