Early Detection Research Network

GPI

Aliases:
This biomarker is also known as:
  • GNPI,
  • phosphoglucose isomerase,
  • Sperm antigen 36,
  • phosphohexose isomerase,
  • sperm antigen-36,
  • AMF,
  • glucose phosphate isomerase,
  • autocrine motility factor,
  • Autocrine motility factor,
  • phosphohexomutase,
  • glucose-6-phosphate isomerase,
  • neuroleukin,
  • NLK,
  • phosphosaccharomutase,
  • hexosephosphate isomerase,
  • hexose monophosphate isomerase,
  • EC 5.3.1.9,
  • GPI,
  • PHI,
  • PGI,
  • Phosphohexose isomerase,
  • oxoisomerase,
  • SA36,
  • Neuroleukin,
  • SA-36,
  • Phosphoglucose isomerase,
  • sperm antigen 36,

Description…

From NCBI Gene: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: GPI

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.