Early Detection Research Network


This biomarker is also known as:
  • neuronal membrane glycoprotein M6-b,
  • GPM6B,
  • M6B,
  • Q13491,
  • M6b,
  • MGC17150,
  • MGC54284,
  • glycoprotein M6B,
  • protolipid M6B,


GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is expressed in the brain and may be involved in cellular housekeeping functions. GPM6B is involved in the regulation of osteoblast function and bone formation and matrix vesicle release by osteoblasts. GPM6B may be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


GPM6B has been investigated as a serum biomarker for ovarian cancer as reported in European journals.

Performance Comment

GPM6B was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. GPM6B was not in the group of 13 selected for further validation.


Phase: One
QA State: Under Review


Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.