Early Detection Research Network

GSTM3

Aliases:
This biomarker is also known as:
  • glutathione S-aryltransferase M3,
  • brain type mu-glutathione S-transferase,
  • glutathione S-transferase, Mu-3,
  • GTM3,
  • GSTM3-3,
  • glutathione S-transferase Mu 3,
  • glutathione S-transferase M3 (brain),
  • brain GST,
  • hGSTM3-3,
  • glutathione S-transferase mu 3 (brain),
  • glutathione S-aralkyltransferase M3,
  • glutathione S-alkyltransferase M3,
  • S-(hydroxyalkyl)glutathione lyase M3,
  • GSTM3,
  • GSTB,
  • EC 2.5.1.18,
  • GST5,
  • GST class-mu 3,

Description…

The GSTM3 gene product is glutathione S-transferase mu 3. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: GSTM3

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.