Early Detection Research Network

HAMP

Aliases:
This biomarker is also known as:
  • HEPCIDIN,
  • hepcidin,
  • Liver-expressed antimicrobial peptide 1,
  • HFE2B,
  • PLTR,
  • Putative liver tumor regressor,
  • LEAP1,
  • HAMP,
  • HEPC,
  • hepcidin-25,
  • hepcidin antimicrobial peptide,
  • LEAP-1,

Description…

HEPC, also known as HAMP, is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: HAMP

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

HAMP alone or as a member of a panel was not a strong predictor of ovarian cancer. CA125 alone remains a more effective biomarker.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. HAMP alone was not a strong predictor.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.