Early Detection Research Network

Hanash 3 marker panel for Lung Cancer

This biomarker is also known as:
  • Hanash 3 marker panel for Lung Cancer,
  • Hanash 3-marker panel for Lung Cancer,


The EDRN validation study ("Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques") presents evidence for the occurrence in lung cancer sera of autoantibodies to annexin 1, 14-3-3 theta and LAMR1, which precede the onset of symptoms and diagnosis. The combined AUC for these three antigens in CARET pre-clinical lung cancer sera vs. matched controls was 0.73. While autoantibodies to various cancer antigens have been reported in newly diagnosed lung cancer patient sera, an important aspect of this study is testing for occurrence of autoantibodies in pre-diagnostic sera and demonstration of significant autoantibody reactivity against LAMR1, annexin 1 and 14-3-3 theta.


There are no datasets associated with this biomarker.

QA State: Accepted
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…


Phase: Three
QA State: Under Review


This study provides evidence for a predictive effect, in pre-diagnostic lung cancer sera, of a 3-biomarker panel for lung cancer. The panel is comprised of three antigens, annexin 1, LAMR1 and 14-3-3 theta.

Performance Comment

The findings of this study suggest potential utility of an approach to diagnosis of lung cancer before onset of symptoms that includes screening for autoantibodies to defined antigens. Investigation of annexin 1 (ANXA1), 14-3-3 theta (YWHAQ) and LAMR1 (RPSA) is ongoing.

Supporting Study Data

The following studies/protocols provide evidence supporting Hanash 3 marker panel for Lung Cancer indications for the Lung…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

No associated publications found.

No other associated resources found.