Early Detection Research Network

HMGB1

Aliases:
This biomarker is also known as:
  • high-mobility group box 1,
  • SBP-1,
  • High mobility group protein B1,
  • high mobility group protein 1,
  • Amphoterin,
  • HMG3,
  • HMG1,
  • high-mobility group (nonhistone chromosomal) protein 1,
  • DKFZp686A04236,
  • HMGB1,
  • high mobility group box 1,
  • Sulfoglucuronyl carbohydrate binding protein,

Description…

Nuclear protein HMGB1 is a DNA-binding protein that associates with chromatin and has the ability to bend DNA. It binds preferentially single-stranded DNA. HMGB1 is involved in V(D)J recombination by acting as a cofactor of the RAG complex. It acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: HMGB1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.