Early Detection Research Network

HOXA9

Aliases:
This biomarker is also known as:
  • homeobox protein Hox-1G,
  • Homeobox protein Hox-1G,
  • P31269,
  • HOX1,
  • HOX1.7,
  • homeo box A9,
  • homeobox A9,
  • ABD-B,
  • HOX1G,
  • HOXA9,
  • homeobox protein Hox-A9,
  • homeodomain protein HOXA9,

Description…

HOXA9 is a sequence-specific transcription factor. It is a member of the homeobox gene family. These transcription factors are spatially and temporally regulated during embryonic development. HOXA9 is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: HOXA9

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

HOXA9 and NID2 have been identified as novel differentially methylated genes in oral squamous cell carcinoma. These genes were also shown to have significantly higher methylation levels in tumor than normal oral mucosa, as seen by ROC analysis of head and neck squamous cell carcinoma samples.

Performance Comment

HOXA9 and NID2 are promising oral squamous cell carcinoma biomarkers that should be studied on tissue, saliva and serum from larger cohorts. HOXA9 and NID2 were chosen for further study because they were the only candidate genes that had an AUC value equal to or higher than 0.75, and 100% specificity and sensitivity higher than 70%.

Attributes

Phase: Two
QA State: Under Review

Overview

DNA methylation of HOXA9 has been found to be associated with ovarian cancer.

Performance Comment

HOXA9 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. HOXA9 was not in the group of 13 selected for further validation.

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.