Early Detection Research Network

HYAL2

Aliases:
This biomarker is also known as:
  • LUCA2,
  • Lung carcinoma protein 2,
  • lysosomal hyaluronidase,
  • Hyaluronoglucosaminidase-2,
  • EC 3.2.1.35,
  • PH20 homolog,
  • lung carcinoma protein 2,
  • PH-20 homolog,
  • hyaluronidase-2,
  • hyaluronoglucosaminidase 2,
  • Hyal-2,
  • hyal-2,
  • hyaluronidase 2,
  • hyaluronoglucosaminidase-2,
  • LuCa-2,

Description…

HYAL2, or hyaluronoglucosaminidase 2, is a weak acid-active hyaluronidase. HYAL2 breaks down hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The HYAL2 gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. There are two known alternatively spliced transcript variants.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Under Review
Type: Protein
Short Name:
HGNC Name 3: HYAL2

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.