Early Detection Research Network

IGFBP1

Aliases:
This biomarker is also known as:
  • alpha-pregnancy-associated endometrial globulin,
  • IGF-BP25,
  • insulin-like growth factor binding protein 1,
  • IGFBP-1,
  • IGFBP1,
  • IBP-1,
  • AFBP,
  • Placental protein 12,
  • hIGFBP-1,
  • PP12,
  • IBP1,
  • IGF-binding protein 1,

Description…

IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP1 promotes cell migration.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: IGFBP1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

IGFBP1 has not been shown to be a strong biomarker for ovarian cancer.

Performance Comment

Of the ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. IGFBP1 alone was not a strong predictor.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.